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Frontiers | Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity

Natto Department of Disease Control and Environmental Health, Makerere University, Kampala, Uganda Rawlance Ndejjo School of Pharmacy, West Virginia University, Morgantown, WV, USA Sabina Onyinye Nduaguba Department of General Surgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Ionut Negoi, Dragos Serban & Bogdan Socea Department of General Surgery, Emergency Hospital of Bucharest, Bucharest, Romania Ionut Negoi Department of Anatomy and Embryology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Ruxandra Irina Negoi Department of Cardiology, Cardio-Aid, Bucharest, Romania Ruxandra Irina Negoi Department of Epidemiology, Non-Communicable Diseases Research Center (NCDRC), Tehran, Iran Seyed Aria Nejadghaderi & Sina Rashedi Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece Evangelia Nena & Paschalis Steiropoulos Department of Community Medicine, Kathmandu University, Palpa, Nepal Samata Nepal School of Nursing, University of Gondar, Gondar, Ethiopia Henok Biresaw Netsere College of Medicine and Health Science, Bahir Dar University, Gondar, Ethiopia Henok Biresaw Netsere Department of Public Health, University of Yaoundé I, Yaoundé, Cameroon Georges Nguefack-Tsague Department of Biological Sciences, University of Embu, Embu, Kenya Josephine W

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In vivo , we xenografted nude mice with MCF-7 shTrx-1 cells (Trx-1 stably knocked down) or with MCF-7 shControl cells (control shRNA) (see Materials and methods and Additional file 5)